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KMID : 0388019950060030157
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Korean Journal Gynecologic Oncology and Colposcopy
1995 Volume.6 No. 3 p.157 ~ p.165
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Proliferating Cell Nuclear Antigen: Relation to Histologic Grade and Prognosis
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Abstract
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The measurement of tumor cell proliferation is becoming increasingly recognized in defining prognostic groups. Proliferating cell nuclear antigne(PCNA) immunolocalization can be used as an index of cell proliferation and may define the extent
depature
from normal growth control.
PCNA is considered to be marker of cell proliferation. The aim of this study was to evaluate the expression of PCNA in epithelial ovarian cancer as well as the possible correlation with degree of differentiation, tumor stage and overall survival.
The material consisted of 35 epithelial ovarian cancer.
The PCNA labelling index (LI) ranged from 7.5% to 92.5% with a median value of 46.7%.
PCNA labelling index (LI) is 30% in grade 1, 63% in grade 2, and 100% in grade 3 in epithelial ovarian cancer(P<0.05). Also, anpositive correlation was found between PCNA labelling index (LI) and clinical stage (P<0.05).
The estimated 3 year survival in patients with a tumor LI below the median(low proliferative group) was higher than those with a tumor LI greater than the median(high proliferation group) (87.5% VS 50%, P<0.05).
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